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. Author manuscript; available in PMC: 2020 May 9.
Published in final edited form as: J Med Chem. 2019 Apr 30;62(9):4669–4682. doi: 10.1021/acs.jmedchem.9b00274

Scheme 2.

Scheme 2.

Alternative linear synthesis for subtype 12

aReagents and conditions: a) Diethylmalonate, NaOEt, EtOH, reflux, o. n., 86%; b) POCl3, BnEt3NCl, 50 °C, 6 h, 70%; c) aniline derivative, EtOH, 150 °C, 30 min, MW, 55–80%; d) DMF, 110 °C, 30 min, MW, 50–69%.