Figure 5. AON-S Ganglion Cell Spatio-temporal Receptive Fields Widen Spatially and Slow Temporally after Cone Loss.
(A) Example stimuli at two points in time where the intensity of each bar is randomly drawn from a Gaussian distribution.
(B) Voltage response of an AON-S ganglion cell in current clamp. Arrowhead indicates the onset of the stimulus fluctuations on a mean background.
(C) One spatial slice of the temporal filter (left) and nonlinearity (right) calculated for a cell from control retina.
(D and E) Spatio-temporal receptive field obtained from a correlation of the response with the stimulus where red and blue represent opposite polarity responses for AON-S ganglion cells recorded in control (D) and DTR (E) retina.
(F) Spatial receptive field for the cells shown in (D) and (E) taken for dominant principal components. (Inset) Difference of Gaussians fit (green) for each cell.
(G) Temporal filters from the first principal components of the cells from (D) and (E).
(H and I) Parameters of the difference of Gaussians fit show significantly narrower centers (H) and wider surrounds (I) for DTR receptive fields. Asterisks indicate significance (see Results). Boxplots show median with interquartile range (IQR) and whiskers from 10% to 90% of the data (see Figure S5).
(J) No significant difference was observed in the ratio of center and surround weights between control and DTR. Box plots show median with interquartile range and whiskers from 10% to 90% of the data.
(K) Time to peak of the temporal receptive fields for DTR cells are significantly slower than control cells. Box plots show median with interquartile range and whiskers from 10% to 90% of the data.
See also Figure S5.