Figure 7. Excitation and Inhibition Drive Different Components of AON-S Ganglion Cell Receptive Field Changes after Cone Loss.
(A and B) Spatio-temporal receptive field obtained from excitatory currents onto an AON-S ganglion cell recorded in voltage clamp at −60 mV in control (A) and DTR (B) retina.
(C and D) Spatio-temporal receptive field obtained from inhibitory currents onto an AON-S ganglion cell recorded in voltage clamp at +10 mV in control (C) and DTR (D)retina.
(E–G) Gaussian fit parameters for receptive fields measured from excitatory currents.
(E) Excitatory currents show significantly narrower centers after cone loss, although (F) show no change in surround widths after cone loss.
(G) The center-to-surround weights increase after cone loss.
(H) Time to peak of the temporal receptive fields is significantly slower.
(I–K) Gaussian fit parameters for receptive fields measured from inhibitory currents.
(I) Inhibitory currents show no change in center widths after cone loss, although (J) show significantly wider surrounds after cone loss.
(K) The center-to-surround weights are unchanged.
(L) Time to peak of the temporal receptive fields is significantly slower. Asterisks indicate significance (see Results).
(E–L) Boxplots show median with IQR and whiskers from 10% to 90% of the data.