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. 2019 Jul 11;9:10070. doi: 10.1038/s41598-019-46431-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Metabolomic analysis of diseased, treated, and normal skeletal muscle. (a) A principal component analysis (PCA) plot and (b) a heatmap depicting hierarchical clustering analysis (HCA) from quadriceps muscles derived from 52-week old C57BL/6, AAV9-hFKRP-treated, and untreated FKRP^P448L mice were calculated using the Euclidian distance metrics. In the PCA plot, male and female subjects are identified by circles and squares, respectively. In both plots, C57BL/6 samples are identified by blue symbols, AAV9-hFKRP-treated samples by green symbols, and untreated FKRP^P448L samples by orange symbols.