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. 2019 Jul 11;10:3051. doi: 10.1038/s41467-019-11082-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Apoptosis profiles of liver metastatic lesion and parenchyma. a Immunofluorescence micrographs showing the expression of active Caspase 3 (labeled in red) in both metastasis (GFP positive, green) and pan-cancer, normal parenchyma (GFP negative). Scale bars: 80 μm (left) and 20 μm (right). b, c Flow-cytometry results showing the intracellular cleaved-PARP expression. The freshly harvested liver tissues from mice received different treatments were digested and sorted using flow-cytometry on the basis of the expression of the GFP protein, sequentially followed by fixation, permeabilization, and staining with phycoerythrin (PE)-labeled cleaved-PARP antibody. d Changes of cleaved-PARP expression in b metastasis and c liver parenchyma. The averaged value of three independent tests was normalized to that of the control group; data are presented as mean ± s.e.m. (n = 3). P values were calculated by one-way ANOVA (***p < 0.001, **p < 0.005)