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. 2019 Jul 11;10:3051. doi: 10.1038/s41467-019-11082-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Changes in gene expression. a A heat map showing the expression levels of 5542 identified genes in liver metastasis lesions of mice received different treatments. Treatments (from top to bottom row): Mito(T)-pep-Nuc(T), Mito(T)-pep-Nuc(N), Mito(N)-pep-Nuc(T), Sorafenib, and PBS. b, c Charts showing the total number of enriched annotations for b up-regulated and c down-regulated genes whose differences in expression are of statistical significance. Four categories, including biological process, cellular components, molecular function, and KEGG pathway, were considered. d, e Top-10 significantly enriched GO annotations associated with d up-regulated and e down-regulated genes belonging to the term of Biological Process, Cell Component, and Molecular Function