Fig. 8.

Proteome study. a Networks showing the corresponding down-regulated proteins identified by LC/MS that interact with three different organelles, including endoplasmic reticulum, mitochondria, and nuclei. Potential form of phosphorylation of each protein is shown below. b A heat map showing the enriched proteins that were associated with five classes of functions: ER stress, GLY, ATP production, cell cycle arrest, and intrinsic apoptosis. The bioinformatic analysis was conducted using Omicsbean Cancer software. A color bar on the right indicates the color scales. c A schematic illustrating the network of possible pathways underlying the therapeutic effect of Mito(T)-pep-Nuc(T) in cancer cells