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. Author manuscript; available in PMC: 2019 Jul 12.
Published in final edited form as: Arch Toxicol. 2014 Mar 13;88(9):1749–1763. doi: 10.1007/s00204-014-1223-9

Figure 2: miRNA profilings indicate miR-34 family elevation in limbs destined to be malformed.

Figure 2:

miRNA dysregulation is mostly identified in limb buds destined to be malformed compared to resistant limb buds: (A) 24 hours following injection with 5-aza on GD 10/12 (mice [left] and rats [right], respectively); (B) 24 hours following GD 10 injection with a teratogenic dose (0.5 mg/Kg) versus a sub-threshold dose (0.15 mg/Kg). (C) Expression of miRNAs that showed a dose-dependant upregulation in mice and rats hindlimbs, with either limited or no upregulation in the forelimbs. ‘M’/’N’ indicates Malformed/Normal limb development.