Table 2. Grading of PDAC [adapted from (13)].
Criteria | G1 | G2 | G3 |
---|---|---|---|
Architecture | Tubular, middle-sized duct-like structures, papillary projections | Middle and small-sized duct-like structures, cribriform structures | Solid areas, budding, single cell infiltration |
Cells | Cylindrical, retained mucin | Cubic, partial loss of mucin | Polygonal, pleomorphic, spindle, loss of mucin production |
Nuclei | Slightly polymorphous | Moderately polymorphous | Very polymorphous |
Mitoses | 1–5/10 HPF | 6–10/10 HPF | >10/10 HPF |
PDAC, pancreatic ductal adenocarcinoma.