Figure 1.

SETD7 expression, recruitment/occupancy, and function during cardiomyocyte development. Depicted at the top are human embryonic stem cells (ESC) as they are progressively differentiated into mesoderm (MES), cardiac progenitors (CP), and terminally-differentiated cardiomyocytes (CM). Shown below are SETD7 relative expression levels, SETD7 target genes (based on SETD7 ChIP occupancy profiles combined with RNA-seq data identifying misexpressed genes in SETD7 knockdown cells as compared to controls), factors believed to recruit/localize SETD7 to promoters and gene bodies, and SETD7 function at different stages (based on SETD7 knockdown phenotypes).