Table 1.
Summary of pharmacokinetic parameters of navoximod following oral and IV administration (part 1)
| Parameter | Oral: 200 mg tablet (n = 16) | IV: 5 mg solution (n = 16) |
|---|---|---|
| AUC(0–∞) (h.ng/mL) | 1790 (31.4) | 80.6 (21.0) |
| AUC(0–72) (h.ng/mL) | 1770 (31.3) | 79.1 (21.3) |
| C max (ng/mL) | 683 (42.2) | 114 (70.7) |
| t max (h)a | 0.5 (0.25–1.02) | 0.0833 (0.0833–0.583) |
| t 1/2 (h)b | 11.0 (6.96–14.3) | 12.6 (9.22–20.4) |
| CL/F or CL (L/h) | 112 (31.4) | 62.0 (21.0) |
| Vz/F or Vz(L) | 1780 (31.9) | 1120 (28.4) |
| F | 0.555 (22.3) | ‐‐ |
Geometric mean (geometric CV%) results are presented unless otherwise indicated.
a
Median (minimum, maximum) results are presented for tmax.
b
Geometric mean (range) results are presented for t1/2.