Table 2.
Mean pharmacokinetic parameters for radioactivity in plasma and whole blood following administration of 200 mg/600 μCi [14C]‐navoximod
| Parameter | Plasma navoximod (n = 8) | Plasma total radioactivity (n = 8) | Whole blood total radioactivity (n = 8) |
|---|---|---|---|
| AUC(0‐∞) (h.ng/mL)a | 1540 (31.3) | 36,700 (32.0) | 38,900 (55.4) |
| AUC(0‐last) (h.ng/mL)b | 1510 (31.6) | 31,000 (27.2) | 22,500 (39.9) |
| C max (ng/mL)a | 464 (33.1) | 4400 (30.8) | 2340 (28.7) |
| t max (h)c | 0.5 (0.25–1.5) | 0.75 (0.5–1.5) | 0.5 (0.5–1.5) |
| t 1/2 (h)d | 9.41 (7.54–12.8) | 143 (79.6–190) | 206 (64.3–336) |
| CL/F (L/h) | 124 (31.4) | 5.22 (32.0) | 4.92 (55.4) |
| Vz/F (L) | 1680 (29.7) | 1080 (19.7) | 1460 (27.5) |
Geometric mean (geometric CV%) results are presented unless otherwise indicated.
a
Units for total radioactivity are h.ng equivalents/g for AUC(0‐last) and AUC(0‐∞), and ng equivalents/g for C max.
b
AUC(0‐last): Last measurable concentration is 336 h unless the subject discontinued early or fulfilled discharge criteria prior to 336 h.
c
Median (minimum, maximum) results are presented for t max.
d
Geometric mean (range) results are presented for t 1/2.