Table 5.
Simulated area under the concentration–time curve from time of dosing to 24 h after administration (AUC24h) of ipragliflozin and change in urinary glucose excretion for 24 hours (ΔUGE24h) at steady‐state after 50 mg daily dose by renal function classification
| Renal function | n | AUC24h (ng h/mL) | ΔUGE24h (g) |
|---|---|---|---|
| Normal (eGFR ≥90) | 318 | 5083 (3010–8022) | 86 (66–136) |
| Mild impairment (eGFR 60 to <90) | 466 | 5474 (3318–8835) | 89 (54–154) |
| Moderate impairment (eGFR 30 to <60) | 103 | 5969 (3872–9358) | 65 (29–120) |
Median (2.5th–97.5th percentile) are presented by renal function classification.
eGFR, estimated glomerular filtration rate