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. 2019 Jun 14;85(8):1740–1750. doi: 10.1111/bcp.13960

Table 4.

Comparison of the doses proposed to achieve area under the curve up to 12 hours (AUC0–12 h) of 120–150 ng/mL h for TAC twice daily (TD) and AUC0–24h of 240–300 ng/mL h for TAC once daily (OD) using Bayesian AUC estimates as compared to the reference, trapezoidal AUCs (only the best limited sampling strategies (LSS) for each period are presented)

Patient Proposed dose (mg)
Number Dose (mg) Referencea ITSIM Pmetrics
TAC OD D7
LSS 0,1 and 6 h
1 4 4.5–6.0 6.0–7.5 8.0–10.0
2 17 13.5–17.0 = 14.0–17.5 = 16.0–20.0 =
3 18 14.0–17.5 14.5–18.5 = 16.0–20.5 =
4 15 11.5–14.0 12.0–14.5 13.0–16.0 =
5 15 15.0–19.0 = 16.0–20.0 15.5–19.0
6 23 9.5–12.0 10.5–13.0 9.5–11.0
7 3 6.5–8.5 6.0–7.5 6.0–7.5
8 23 17.0–21.0 17.0–11.5 16.0–20.0
9 6 7.0–9.0 8.0–10.0 8.0–10.0
10 15 10.5–13.0 10.5–13.0 10.0–12.5
TAC OD W6
LSS 0,1 and 6 h
1 11 9.0–11.0 = 9.5–11.5 = 8.5–10.5
2 22 18.0–23.0 = 19.0–24.0 = 16.0–20.0
3 15 9.0–11.5 9.5–11.5 8.5–11.0
4 20 10.0–12.0 11.0–14.0 11.5–14.5
5 25 15.5–19.5 14.0–17.5 13.5–17.0
6 12 8.0–10.0 7.5–9.5 8.5–11.0
7 19 11.5–14.0 11.5–14.0 11.0–14.0
8 6 4.0–5.0 3.5–4.55 4.0–4.5
9 25 10.5–13.0 11.0–14.0 11.0–14.0
10 8 6.0–7.5 5.5–7.0 6.0–7.5
TAC TD D7
LSS 0,2 and 6 h
1 4 4.0–5.0 = 4.0–5.0 = 5.0–6.0
2 13 9.0–11.5 = 10.0–12.5 11.5–14.5 =
3 16 7.0–9.0 = 7.5–9.0 7.0–9.0
4 10 10.5–13.0 9.5–12.0 = 10.5–13.0
5 14 23.5–29.5 24.5–30.5 17.0–21.5
6 10 11.0–13.5 11.0–14.0 9.5–12.0 =
7 12 10.0–12.5 = 9.5–12.0 = 9.5–12.0 =
8 14 7.5–9.0 7.5–9.5 8.5–10.5
9 11 6.0–7.0 6.5–8.0 7.0–8.5
10 18 15.0–19.0 = 16.5–21.0 = 18.0–22.5 =
TAC TD W6
LSS 0, 1 and 3 h
1 9.5 10–12.5 9.0–11.5 = 10.0–12.5
2 12 8.5–10.5 8.0–10.0 7.5–9.0
3 14 8.0–10.5 8.5–10.5 8.0–10.0
4 20 12.5–16.0 11.0–14.0 12.50–16.0
5 12 6.5–8.0 6.5–8.0 6.0–7.5
6 18 10.0–12.5 10.0–12.5 8.5–11.0
7 24 16.0–20.0 16.5–21.0 14.0–17.5
8 10 5.5–6.5 5.5–7.0 5.0–6.5
9 12 5.0–6.5 5.5–7.0 7.0–8.5
10 14 10.5–13.0 10.5–13.3 9.0–11.5
a

Reference, Trapezoidal method: proposed dose derived from the trapezoidal AUC0–12 h for TD and AUC0–24 h for OD; Poorly estimated doses are in bold characters; D7, day 7; OD, Advagraf; TAC, tacrolimus; TD, Prograf; W6, week 6.