Table 2.
Distribution of coefficients of variance (CV) for area under the plasma concentration‐time curve (AUC) in pharmacokinetic studies of beta‐adrenergic blocking agents where the CVs were > 40% (high variability)
| Drug | Number (%) of single‐dose studies with CV > 40% for AUC | Number (%) of steady‐state studies with CV > 40% for AUC | References (Supplementary Materials) |
|---|---|---|---|
| Atenolol | 5/36 (14) | 0/4 (0) | 41,42,51,54 |
| Betaxolol | 0/1 (0) | 0/1 (0) | |
| Bisoprolol | 0/10 (0) | 0/2 (0) | |
| Carvedilol | 10/12 (83) | 1/1 (100) | 73,74,76,78,80,81 |
| Labetalol | 5/14 (36) | 1/4 (25) | 55,86,89 |
| Metoprolol | 41/49 (84) | 32/40 (80) | 17,38,58,65,91‐98,100‐107,109‐115,117‐123,126‐131,135‐141 |
| Nadolol | 1/6 (17) | 3/6 (50) | 145,146 |
| Nebivolol | 8/11 (73) | 1/1 (100) | 148‐150,152‐155 |
| Oxprenolol | 1/4 (25) | 2/3 (66) | 122,126,158 |
| Pindolol | 3/11 (27) | 4/7 (57) | 163,165‐167 |
| Propranolol | 40/58 (69) | 36/39 (92) | 38,42,51,59,62,93,95,128,166,170‐172,175‐178,180‐182,184‐186,188‐190,194‐205,207‐214 |
| Sotalol | 0/14 (0) | 1/5 (20) | 222 |
| Timolol | 5/7 (71) | ND | 193,223‐225 |
ND, no data.