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Cellular machinery involved in ubiquitination. protein ubiquitination is driven by E1 (ubiquitin-activating), E2 (ubiquitin-conjugating), and E3 (ubiquitin-ligating) enzymes. Three distinct classes of ubiquitin ligases—RING/U-box (top), HECT (middle), and RBR (bottom)—utilize different structural mechanisms for mediating the final transfer of ubiquitin onto substrates.
