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. 2019 Jul 5;9:239. doi: 10.3389/fcimb.2019.00239

Figure 3.

Figure 3

A. muciniphila strain ATCC and 139 showed strain-specific anti-inflammatory effects on the chronic colitis of mice. (A) Body weight change of mice (normalized to the original weight). Periods of DSS treatment were shadowed. (B) Fecal lipocalin-2 contents. (C) Spleen weight (ratio to body weight). (D) Conlon inflammation index (colon weight/length). (E) Representative hematoxylin-eosin stained sections of distal colon at day 46 and 56 (200×). (F) Histological scores of colon sections. (G) Colon mRNA expression of several pro-inflammatory mediators relative to β-actin in mice. For body weight and fecal lipocalin-2 level, n = 10 per group before 46d time point, n = 5 per group from 46d time point. For other data, n = 5 per group for each time point. Data are shown as means ± s.e.m. Values of each group were calculated by one-way analysis of variance (ANOVA) followed by Tukey's post-hoc test. For graph (A,C–G) *P < 0.05, **P < 0.01, ***P < 0.001. For graph (B), **P < 0.01 compared with DSS group.