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. 2019 Jul 5;9:239. doi: 10.3389/fcimb.2019.00239

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Copyright © 2019 Zhai, Xue, Zhang, Yang, Zhao and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A. muciniphila strain ATCC promoted the MLNs Treg cells differentiation and SCFAs production of mice. (A,B) The frequency of Foxp3+ Treg cells among the CD4+ T cells (CD3+ CD4+ cells) in MLNs of mice at day 46 (n = 5 per group) and day 56 (n = 4 per group) detected by flow cytometry. (C) The content of SCFAs (acetate, propionate, butyrate, iso-butyrate, iso-valeric, and valeric) in cecum content of mice at day 46 and day 56 (n = 5 per group). (D) mRNA expression of GPR43 in colon of mice (n = 5 per group). All the data are shown as mean ± s.e.m. Values of each group were calculated by one-way analysis of variance (ANOVA) followed by Tukey's post-hoc test. *P < 0.05, **P < 0.01.