Table 1.

Common Terminology Criteria for Adverse Events (CTCAE) for diarrhoea and colitis

	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Diarrhoea	Increase of <4 stools per day over baseline; mild increase in ostomy output compared to baseline	Increase of 4–6 stools per day over baseline; moderate increase in ostomy output compared to baseline; limiting instrumental ADL	Increase of ≥7 stools per day over baseline; severe increase in ostomy output compared to baseline; hospitalization indicated; limiting self-care ADL	Life-threatening consequences; urgent intervention indicated	Death
Colitis	Asymptomatic; clinical or diagnostic observations only; intervention not indicated	Abdominal pain; mucus or blood in stool	Severe abdominal pain; peritoneal signs	Life-threatening consequences; urgent intervention indicated	Death

ADL, activities of daily life. Adapted from the Cancer Therapy Evaluation Program, National Cancer Institute, Common Terminology Criteria for Adverse Events (CTCAE) v5.0.