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. 2019 Jul 5;10:869. doi: 10.3389/fphys.2019.00869

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Copyright © 2019 Stožer, Markovič, Dolenšek, Perc, Marhl, Slak Rupnik and Gosak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Features of the phenomenological model of beta cell population. (A) A typical simulated beta cell network architecture. Red dots denote individual cells and the arrows depict intercellular electrical coupling. (B) Simulated time course of beta cell excitability rate after switching from substimulatory to stimulatory (Δα = 0.08, A = 0.45, B = 0.0004, $T_{m, i}^{(8)} = 35000$ , t_s = 10000) and suprastimulatory (Δα = 0.09, A = 0.70, B = 0.0008, $T_{m, i}^{(12)} = 20000$ , t_s = 10000) conditions.