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. 2019 Jul 5;10:869. doi: 10.3389/fphys.2019.00869

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Copyright © 2019 Stožer, Markovič, Dolenšek, Perc, Marhl, Slak Rupnik and Gosak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simulated beta cell responses after switching from a substimulatory to a suprastimulatory level of stimulation, i.e., from 6 to 12 mM glucose. (A) Three characteristic traces of simulated cellular dynamics and the raster plot of binarized cellular activity. The orange dotted line indicates the fraction of active cells within the given time-window that was slid throughout the simulation. (B,D) 3D raster plots showing the excitation waves for selected intervals for the activation (B) and plateau (D) phase. Colors denote individual waves. (C,E) The distributions of excitation wave sizes for the activation (C) and plateau (E) phase. The gray dashed line indicates the power-law fit.