Figure 3.

Development and treatment of complications of type 2 diabetes. Hyperglycemia and dyslipidemia due to overnutrition and genetic predisposition overload tissues with cell nutrients with subsequent tissue damage mediated by inflammatory processes. Overfeeding can be prevented with GLP-1 analogs, hyperglycemia can be reduced via glycosuria using SGLT2 inhibitors, and tissue damage can be alleviated via IL-1β antagonists. In contrast, increasing insulin signaling may enhance nutrient overload in tissues with subsequent induction of a damaging inflammation.