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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Bioorg Med Chem Lett. 2019 Mar 20;29(11):1413–1418. doi: 10.1016/j.bmcl.2019.03.022

Figure 8.

Figure 8

ChDHFR inhibition in the presence of 10 mM DTT. Covalent compounds 15D17 and 15D18 and enzyme were incubated for 16 h with 10 mM DTT before the reaction was initiated. 15D10, the parent compound of 15D17, was used as a negative control.