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. Author manuscript; available in PMC: 2020 Mar 13.
Published in final edited form as: Cell Host Microbe. 2019 Feb 26;25(3):418–431.e6. doi: 10.1016/j.chom.2019.01.005

Figure 7. Genetic and epigenetic mechanisms act together to generate phenotypic heterogeneity in C. albicans.

Figure 7.

(A) Epigenetic switching occurs between white and opaque states. EFG1 is essential for the white state and mutational loss of this gene causes white cells to adopt the gray state. efg1 null cells can still undergo epigenetic switching between gray and opaque-like states. Both opaque and opaque-like states require WOR1 expression. C. albicans therefore uses both genetic and epigenetic mechanisms to adopt different cell states, with EFG1 playing a central role in both mechanisms.

(B) Four alternative cell states are distinguishable on CHROMagar medium.

See also Figure S7.