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. 2019 Jul 11;12:74. doi: 10.1186/s13045-019-0766-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Structure of KCC1 and classification of the CCC family. a Structure. The topology model shown was drawn with the program PLOT by Biff Forbush (Yale University). Branched lines correspond to glycosylation sites, other symbols to residues and colors other than blue, to functional sites of potential importance. b Phylogenetic tree of the CCC family. The phylogram shown was obtained with the programs PhyML v3.1/3.0 aLRT and MUSCLE v3.8.31 [36, 37] using the most abundant human variants. GenBank accession numbers are provided in footnote 11