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Model for the role of Epe1-SAGA interaction in regulating heterochromatin stability. (A) At its normal expression levels, Epe1 weakly interacts with SAGA, resulting in the recruitment of small amount of SAGA to promote transcription for heterochromatin assembly. (B) When Epe1 is overexpressed, it recruits excess SAGA to promote histone acetylation and transcription strong enough to disrupt heterochromatin by transcription-mediated histone turnover.
