Fig. 2.

GEMINI accurately infers individual gene effects and identifies strong interactions. a GEMINI’s individual gene effects for all of Big Papi’s cell lines are shown. Genes (x-axis) are sorted in ascending order according to the inferred individual gene effects (y-axis). Essential genes found by CERES [17] are labeled as “Pan-essential.” b GEMINI “strong” scores (left) versus dLFC FDRs (right) for all gene pairs in the A549 lung cancer cell line from the Big Papi screen. Pairs with GEMINI score above 1 have FDR less than 0.0001 (see Additional file 2: Table S1 for GEMINI’s scores and FDRs). Experimentally or clinically supported interactions are highlighted in black. c GEMINI score, GEMINI FDR, and dLFC FDR for interactions shown in black in part b. dLFC does not find the well-known interactions between BRCA family members and PARP1 while GEMINI finds them highly significant