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. 2019 Jul 12;20:137. doi: 10.1186/s13059-019-1745-9

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© The Author(s) 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Systematic evaluation of GEMINI. a Lethal interactions that were identified by GEMINI in at least four cell lines (Big Papi), colored according to previous findings. Blue indicates interactions validated in Big Papi, green indicates interactions identified by a drug-RNAi screen, red indicates interactions studied in other clinical or experimental contexts, and purple indicates interactions uniquely found by GEMINI that have not been experimentally characterized. Only 3 interactions are found in 4 or more cell lines by other methods (bottom), representing significantly lower sensitivity compared to GEMINI. b PR curve is depicted for GEMINI, π-score, GImap, and dLFC, where GEMINI achieves the highest PR-AUC (0.78)