Fig. 4.

GEMINI identifies interactions common across different combinatorial knockout screens. a Common interactions identified by GEMINI across Big Papi, Shen-Mali, and CDKO screens are shown. Any gene pairs in the top 10% of ranks in at least two screens are shown in red. If a gene pair was not included in the screen, it was labeled as “Not included” (gray). Experimentally or clinically supported interactions are shown in bold, and those identified in SynLethDB are colored by green. b Common interactions across screens are shown in a network where edge weight is adjusted based on evidence scores from STRING. Only interactions with evidence scores above 0.5 are shown. Interactions supported by experimental or clinical findings are emphasized with black edges, and those supported by SynLethDB with green edges