Table 1.
Cross tabulation of numbers of genes (column %) by observed XCI status in ovarian tissue compared with the expected XCI status based on prior studies of normal tissue (based on Balaton et al.)
| Ovarian tumors | |||||
|---|---|---|---|---|---|
| Subject to XCI a | Variable escape from XCI b | Escape from XCI c | Total | ||
| Normal tissue | Subject to XCI | 172 (55.5%) | 0 (0.0%) | 13 (22.4%) | 185 (49.7%) |
| Mostly subject to XCI | 76 (24.5%) | 0 (0.0%) | 7 (12.1%) | 83 (22.3%) | |
| Variable escape from XCI | 12 (3.9%) | 0 (0.0%) | 1 (1.7%) | 13 (3.5%) | |
| Mostly variable escape from XCI | 7 (2.3%) | 0 (0.0%) | 1 (1.7%) | 8 (2.2%) | |
| Escape from XCI | 1 (0.3%) | 1 (25.0%) | 13 (22.4%) | 15 (4.0%) | |
| Mostly escape from XCI | 7 (2.3%) | 0 (0.0%) | 14 (24.1%) | 21 (5.6%) | |
| Discordant across tissues | 18 (5.8%) | 1 (25.0%) | 5 (5.8%) | 24 (6.5%) | |
| No call | 17 (5.5%) | 2 (50.0%) | 4 (5.2%) | 23 (6.2%) | |
| Total | 310 | 4 | 58 | 372 | |
A gene was classified as escaping XCI in a given tumor sample if PPE > 0.5 and subject to XCI if PPE < 0.5.
a
aGenes escaped XCI in > 80% of samples evaluated.
b
bGenes escaped XCI in < 20% of samples evaluated.
c
cGenes escaped XCI in between 20 and 80% of samples evaluated.
d
Genes were not able to be classified in any samples.