Table 2.
Distribution of clinical features by XCI cluster membership
| Regulated cluster (N = 47) | Dysregulated cluster (N = 52) | P-value | ||
| Age at diagnosis, Mean (SD) | 59.1 (12.5) | 64.8 (11.6) | 0.0208b | |
| Grade, N(%) | 1 | 7 (14.9) | 4 (7.7) | 0.0116b |
| 2 | 13 (27.7) | 4 (7.7) | ||
| 3 | 27 (57.4) | 44 (84.6) | ||
| Stage, N(%) | I | 19 (40.4) | 6 (11.5) | 0.00121b |
| II | 5 (10.6) | 5 (9.6) | ||
| III | 17 (36.2) | 30 (57.7) | ||
| IV | 6 (12.8) | 11 (21.2) | ||
| Histotype, N(%) | High-grade serous | 15 (31.9) | 37 (71.2) | 7.1 × 10−5a |
| Endometrioid | 24 (51.1) | 6 (11.5) | ||
| Clear cell | 5 (10.6) | 5 (9.6) | ||
| Mucinous | 1 (2.1) | 2 (3.8) | ||
| Mixed | 2 (4.3) | 2 (3.8) | ||
| Surgical debulking outcome, N(%) | Sub-optimal (residual disease >1 cm) | 18 (38.3) | 39 (75.0) | 0.0002649a |
| Optimal (residual disease ≤1 cm) | 29 (61.7) | 13 (25.0) |
a
aFisher’s exact test.
b
bLinear model.