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. 2019 Jul 11;38:304. doi: 10.1186/s13046-019-1296-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — LEF1 and OV6 expression in ESCC tissues and its clinicopathological characteristics. a Immunochemistry analysis on expression of LEF1 and OV6. Representative staining intensity of LEF1 and OV6 represent different expression levels (scale bar = 100 μm). b Overall survival rate for patients with low LEF1 expression (blue line) and patients with high LEF1 expression (green line), P < 0.01. c The overall survival rates of 95 patients with ESCC were compared with different groups by Kaplan–Meier analysis, P = 0.0002. d The percentage of patients with high LEF1 staining was higher in the OV6-high group. e Correlation between expression levels of OCT4 and LEF1 in ESCC measured by spearman’s rank correlation analysis, Spearman r = 0.214, P = 0.037