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. 2019 Jul 11;38:304. doi: 10.1186/s13046-019-1296-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Overexpression of LEF1 promotes TGF-β signaling pathway. a Heatmap and volcano plot of differentially expressed transcripts. b, c Gene ontology (GO) analysis (b) and pathway analysis (c) based on all identified transcripts. P-value of GO analysis is listed for each category. P-value of pathway is colored in red (P < 0.05) and blue (0.05 < P < 0.1). d Pathway-act network of up-regulated (red) or down-regulated (green) pathways according to pathway database. e Gene expression fold change of TGF-β pathway from RNA-Seq data