Table 4.
Association between MMP3 polymorphism and risk of ankylosing spondylitis under genetics model
| Model | Genotype | Control | Case | OR (95% CI) | p‐value | AIC | BIC | |
|---|---|---|---|---|---|---|---|---|
| rs639752 | Codominant | A/A | 287 (44%) | 117 (43.7%) | 1 | 0.71 | 1,116.1 | 1,130.6 |
| A/C | 309 (47.3%) | 123 (45.9%) | 0.98 (0.72–1.32) | |||||
| C/C | 57 (8.7%) | 28 (10.4%) | 1.20 (0.73–1.99) | |||||
| Dominant | A/A | 287 (44%) | 117 (43.7%) | 1 | 0.93 | 1,114.8 | 1,124.4 | |
| A/C‐C/C | 366 (56%) | 151 (56.3%) | 1.01 (0.76–1.35) | |||||
| Recessive | A/A‐A/C | 596 (91.3%) | 240 (89.5%) | 1 | 0.42 | 1,114.1 | 1,123.8 | |
| C/C | 57 (8.7%) | 28 (10.4%) | 1.22 (0.76–1.96) | |||||
| Log‐additive | — | — | — | 1.05 (0.84–1.31) | 0.67 | 1,114.6 | 1,124.3 | |
| rs520540 | Codominant | G/G | 287 (44%) | 117 (43.7%) | 1 | 0.71 | 1,116.1 | 1,130.6 |
| A/G | 309 (47.3%) | 123 (45.9%) | 0.98 (0.72–1.32) | |||||
| A/A | 57 (8.7%) | 28 (10.4%) | 1.20 (0.73–1.99) | |||||
| Dominant | G/G | 287 (44%) | 117 (43.7%) | 1 | 0.93 | 1,114.8 | 1,124.4 | |
| A/G‐A/A | 366 (56%) | 151 (56.3%) | 1.01 (0.76–1.35) | |||||
| Recessive | G/G‐A/G | 596 (91.3%) | 240 (89.5%) | 1 | 0.42 | 1,114.1 | 1,123.8 | |
| A/A | 57 (8.7%) | 28 (10.4%) | 1.22 (0.76–1.96) | |||||
| Log‐additive | — | — | — | 1.05 (0.84–1.31) | 0.67 | 1,114.6 | 1,124.3 | |
| rs646910 | Codominant | T/T | 534 (81.7%) | 224 (83.6%) | 1 | 0.47 | 1,116 | 1,130.4 |
| A/T | 113 (17.3%) | 43 (16%) | 0.91 (0.62–1.33) | |||||
| A/A | 7 (1.1%) | 1 (0.4%) | 0.34 (0.04–2.78) | |||||
| Dominant | T/T | 534 (81.7%) | 224 (83.6%) | 1 | 0.48 | 1,115 | 1,124.6 | |
| A/T‐A/A | 120 (18.4%) | 44 (16.4%) | 0.87 (0.60–1.28) | |||||
| Recessive | T/T‐A/T | 647 (98.9%) | 267 (99.6%) | 1 | 0.26 | 1,114.2 | 1,123.9 | |
| A/A | 7 (1.1%) | 1 (0.4%) | 0.35 (0.04–2.83) | |||||
| Log‐additive | — | — | — | 0.85 (0.60–1.22) | 0.37 | 1,114.7 | 1,124.3 | |
| rs679620 | Codominant | C/C | 286 (43.9%) | 112 (42%) | 1 | 0.83 | 1,113.3 | 1,127.7 |
| C/T | 306 (46.9%) | 128 (47.9%) | 1.07 (0.79–1.44) | |||||
| T/T | 60 (9.2%) | 27 (10.1%) | 1.15 (0.69–1.90) | |||||
| Dominant | C/C | 286 (43.9%) | 112 (42%) | 1 | 0.59 | 1,111.3 | 1,121 | |
| C/T‐T/T | 366 (56.1%) | 155 (58%) | 1.08 (0.81–1.44) | |||||
| Recessive | C/C‐C/T | 592 (90.8%) | 240 (89.9%) | 1 | 0.67 | 1,111.5 | 1,121.1 | |
| T/T | 60 (9.2%) | 27 (10.1%) | 1.11 (0.69–1.79) | |||||
| Log‐additive | — | — | — | 1.07 (0.86–1.33) | 0.55 | 1,111.3 | 1,120.9 | |
| rs522616 | Codominant | T/T | 270 (41.3%) | 95 (35.7%) | 1 | 0.008 | 1,102.9 | 1,117.3 |
| C/T | 282 (43.1%) | 143 (53.8%) | 1.44 (1.06–1.96) | |||||
| C/C | 102 (15.6%) | 28 (10.5%) | 0.78 (0.48–1.26) | |||||
| Dominant | T/T | 270 (41.3%) | 95 (35.7%) | 1 | 0.12 | 1,108.1 | 1,117.7 | |
| C/T‐C/C | 384 (58.7%) | 171 (64.3%) | 1.27 (0.94–1.70) | |||||
| Recessive | T/T‐C/T | 552 (84.4%) | 238 (89.5%) | 1 | 0.04 | 1,106.3 | 1,116 | |
| C/C | 102 (15.6%) | 28 (10.5%) | 0.64 (0.41–0.99) | |||||
| Log‐additive | — | — | — | 1.01 (0.82–1.24) | 0.92 | 1,110.5 | 1,120.2 |
Abbreviation: AIC, Akaike information criterion; BIC, Bayesian Information Criterions; CI, Confidence interval; OR, Odds ratio; SNPs, Single nucleotide polymorphisms.
p < 0.05 indicates statistical significance.