Table 3.
Association between candidate SNPs and the risk of RA under genotype models
| SNP | Model | Genotype | Genotype frequency | OR (95% CI) | p‐value | |
|---|---|---|---|---|---|---|
| Case | Control | |||||
| IL2RA | ||||||
| rs12569923 | Codominant | G/G | 327 | 316 | 1 | 0.314 |
| C/G | 154 | 172 | 1.15 (0.88–1.50) | |||
| C/C | 18 | 19 | 1.07 (0.55–2.09) | |||
| Dominant | G/G | 327 | 316 | 1 | 0.320 | |
| G/C‐C/C | 172 | 191 | 1.14 (0.88 –1.48) | |||
| Recessive | G/G‐G/C | 481 | 488) | 1 | 0.938 | |
| C/C | 18 | 19 | 1.03 (0.53–1.98) | |||
| Log‐additive | — | — | — | 1.11 (0.88–1.38) | 0.379 | |
| rs791588 | Codominant | T/T | 217 | 183 | 1 | 0.001* |
| G/T | 248 | 237 | 0.88 (0.67–1.15) | |||
| G/G | 42 | 79 | 0.45 (0.29–0.69) | |||
| Dominant | T/T | 217 | 183 | 1 | 0.046* | |
| G/T‐G/G | 290 | 316 | 0.77 (0.60–0.99) | |||
| Recessive | T/T‐G/T | 465 | 420 | 1 | 0.0003* | |
| G/G | 42 | 79 | 0.48 (0.32–0.72) | |||
| Log‐additive | — | — | — | 0.73 (0.61–0.88) | 0.001* | |
| rs12722498 | Codominant | T/T | 398 | 392 | 1 | 0.392 |
| C/T | 106 | 96 | 1.09 (0.80–1.48) | |||
| C/C | 3 | 7 | 0.43 (0.11–1.66) | |||
| Dominant | T/T | 398 | 392 | 1 | 0.776 | |
| T/C‐C/C | 109 | 103 | 1.04 (0.77–1.42) | |||
| Recessive | T/T‐T/C | 504 | 488 | 1 | 0.209 | |
| C/C | 3 | 7 | 0.42 (0.11–1.63) | |||
| Log‐additive | — | 0.99 (0.75–1.32) | 0.977 | |||
| IL2RB | ||||||
| rs2281089 | Codominant | G/G | 300 | 266 | 1 | 0.149 |
| G/A | 178 | 195 | 0.81 (0.62–1.05) | |||
| A/A | 29 | 37 | 0.69 (0.41–1.15) | |||
| Dominant | G/G | 300 | 266 | 1 | 0.062 | |
| A/G‐A/A | 207 | 232 | 0.79 (0.61–1.01) | |||
| Recessive | G/G‐A/G | 478 | 461 | 1 | 0.269 | |
| A/A | 29 | 37 | 0.75 (0.45–1.25) | |||
| Log‐additive | — | — | — | 0.81 (0.67–1.00) | 0.052 | |
| rs3218264 | Codominant | T/T | 116 | 124 | 1 | 0.781 |
| C/T | 268 | 257 | 1.11 (0.82–1.51) | |||
| C/C | 123 | 118 | 1.11 (0.77–1.58) | |||
| Dominant | T/T | 116 | 124 | 1 | 0.482 | |
| T/C‐C/C | 391 | 375 | 1.11 (0.83–1.48) | |||
| Recessive | T/T‐T/C | 384 | 381 | 1 | 0.846 | |
| C/C | 123 | 124 | 1.03 (0.77–1.38) | |||
| Log‐additive | — | — | — | 1.05 (0.88–1.26) | 0.581 | |
| rs1573673 | Codominant | T/T | 209 | 193 | 1 | 0.678 |
| C/T | 239 | 248 | 0.89 (0.68–1.16) | |||
| C/C | 59 | 57 | 0.96 (0.63–1.45) | |||
| Dominant | T/T | 209 | 193 | 1 | 0.423 | |
| T/C‐C/C | 298 | 305 | 0.90 (0.70–1.16) | |||
| Recessive | T/T‐T/C | 448 | 421 | 1 | 0.908 | |
| C/C | 59 | 57 | 1.02 (0.69–1.51) | |||
| Log‐additive | — | — | — | 0.94 (0.78–1.15) | 0.589 | |
Abbreviations: AIC, Akaike's information criterion; BIC, Bayesian information criterion; CI, confidence interval; OR, odds ratios, RA, rheumatoid arthritis; SNP, single‐nucleotide polymorphism.
p values were calculated from Wald's test adjusted for age and sex.
*
p ≤ 0.05 indicates statistical significance.