Table 4.
Association between sex and age stratification and RA risk in allele and genotype models
| SNP | Alleles | Male | Female | Age ≤ 54 | Age﹥54 | ||||
|---|---|---|---|---|---|---|---|---|---|
| OR(95% CI) | pa | OR(95%CI) | pa | OR(95% CI) | pb | OR(95% CI) | pb | ||
| IL2RA | |||||||||
| rs12569923 | G/G | 1 | 0.353 | 1 | 0.739 | 1 | 0.675 | 1 | 0.189 |
| G/C | 1.45 (0.86–2.47) | 1.05 (0.77–1.44) | 1.08 (0.74–1.59) | 1.29 (0.88–1.90) | |||||
| C/C | 0.89 (0.23–3.44) | 1.14 (0.53–2.45) | 1.23 (0.46–3.30) | 1.11 (0.44–2.76) | |||||
| G | 1 | 0.321 | 1 | 0.616 | 1 | 0.983 | 1 | 0.247 | |
| C | 1.25 (0.81–1.92) | 1.07 (0.13–0.83) | 0.99 (0.73–1.36) | 1.20 (0.88–1.64) | |||||
| rs791588 | T/T | 1 | 0.003* | 1 | 0.006* | 1 | 0.001* | 1 | 0.009* |
| G/T | 0.46 (0.27–0.78) | 1.11 (0.81–1.51) | 0.76 (0.52–1.11) | 0.90 (0.61–1.33) | |||||
| G/G | 0.35 (0.16–0.77) | 0.49 (0.30–0.82) | 0.37 (0.21–0.68) | 0.43 (0.23–0.81) | |||||
| T | 1 | 0.001* | 1 | 0.085 | 1 | 0.011* | 1 | 0.056 | |
| G | 0.54 (0.38–0.78) | 0.83 (0.67–0.13) | 0.72 (0.56–0.93) | 0.77 (0.59–1.01) | |||||
| rs12722498 | T/T | 1 | 0.186 | 1 | 0.766 | 1 | 0.598 | 1 | 0.897 |
| T/C | 1.52 (0.82–2.82) | 0.97 (0.67–1.39) | 1.12 (0.73–1.72) | 1.03 (0.65–1.64) | |||||
| C/C | — | 0.58 (0.14–2.48) | 0.95 (0.21–4.33) | — | |||||
| T | 1 | 0.495 | 1 | 0.681 | 1 | 0.703 | 1 | 0.673 | |
| C | 1.21 (0.69–2.13) | 0.93 (0.67–1.28) | 1.09 (0.74–1.58) | 0.91 (0.60–1.39) | |||||
| IL2RB | |||||||||
| rs2281089 | G/G | 1 | 0.210 | 1 | 0.047* | 1 | 0.004* | 1 | 0.784 |
| G/A | 1.06 (0.63–1.77) | 0.73 (0.54–0.99) | 0.54 (0.37–0.79) | 1.16 (0.79–1.71) | |||||
| A/A | 0.38 (0.11–1.28) | 0.78 (0.44–1.40) | 0.57 (0.29–1.15) | 1.09 (0.48–2.52) | |||||
| G | 1 | 0.377 | 1 | 0.087 | 1 | 0.001 | 1 | 0.406 | |
| A | 0.83 (0.55–1.25) | 0.81 (0.65–1.03) | 0.62 (0.46–0.82) | 1.14 (0.85–1.54) | |||||
| rs3218264 | T/T | 1 | 1.239 | 1 | 0.782 | 1 | 0.844 | 1 | 1.049 |
| T/C | 1.45 (0.80–2.64) | 0.95 (0.67–1.35) | 1.04 (0.68–1.59) | 1.08 (0.70–1.66) | |||||
| C/C | 1.24 (0.60–2.59) | 0.94 (0.62–1.43) | 0.89 (0.53–1.51) | 0.85 (0.51–1.42) | |||||
| T | 1 | 0.547 | 1 | 1 | 0.876 | 1 | 0.476 | ||
| C | 1.11 (0.79–1.55) | 0.97 (0.79–1.19) | 0.98 (0.77–1.25) | 0.90 (0.70–1.17) | |||||
| rs1573673 | T/T | 1 | 0.173 | 1 | 0.666 | 1 | 0.134 | 1 | 1.148 |
| T/C | 0.73 (0.43–1.23) | 0.95 (0.70–1.29) | 0.75 (0.52–1.09) | 1.01 (0.67–1.49) | |||||
| C/C | 1.06 (0.51–2.22) | 0.89 (0.54–1.48) | 1.15 (0.63–2.07) | 0.74 (0.40–1.36) | |||||
| T | 1 | 0.791 | 1 | 0.662 | 1 | 0.980 | 1 | 0.351 | |
| C | 0.95 (0.67–1.35) | 0.95 (0.77–1.18) | 0.99 (0.77–1.29) | 0.88 (0.68–1.14) | |||||
Abbreviations: 95% CI, 95% confidence interval; OR, odds ratio; RA, rheumatoid arthritis; SNP, single‐nucleotide polymorphism.
pa‐values were calculated from Wald's test adjusted for age.
pb‐values were calculated from Wald's test adjusted for gender.
*
p < 0.05 indicates statistical significance.