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. 2019 Jul 5;7:161. doi: 10.3389/fbioe.2019.00161

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Copyright © 2019 Kargozar, Montazerian, Fiume and Baino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The mechanisms proposed for the action of strontium ranelate (SrR) on the bone cells. SrR can stimulate bone formation through activating some well-known receptors such as the calcium-sensing receptor (CaSR) and increasing prostaglandin E2 (PE2) production by osteoblasts. In contrast, SrR can inhibit bone resorption via increasing osteoprotegerin and decreasing receptor activator of nuclear factor kappa B ligand (RANK) expression by osteoblasts. Adapted from Marie (2007) with permission.