Table 4.
Effect of pentoxifylline plus berberine on the anthropometric variables, biochemical and inflammatory biomarkers in diclofenac-induced acute kidney injury
| Variable | AKI (n=10) | Pentoxifylline + berberine (n=10) | P |
|---|---|---|---|
| BMI (g/cm2) | 0.64±0.03 | 0.62±0.02 | 0.01¶ |
| Blood urea (mg/dL) | 70.50±12.53 | 29.50±10.60 | 0.0001* |
| Serum creatinine (mg/dL) | 1.52±0.49 | 0.56±0.001 | 0.0001* |
| eGFR (ml/min/1.73) | 7.59±1.7 | 22.97±5.33 | 0.0001* |
| KIM-1 (pg/mL) | 269.03±29.61 | 42.08±7.57 | 0.0001* |
| NGAL (pg/mL) | 18.76±4.13 | 13.37±2.85 | 0.008* |
*P<0.01; ¶P<0.05 unpaired t-test. BMI: Body mass index, eGFR: Estimated glomerular filtration rate, KIM-1: Kidney injury molecule-1, NGAL: Neutrophil gelatinase-associated lipocalin, AKI: Acute kidney injury