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. Author manuscript; available in PMC: 2019 Jul 12.
Published in final edited form as: Structure. 2017 Sep 14;25(10):1519–1529.e4. doi: 10.1016/j.str.2017.08.002

Figure 6. Structural Remodeling in Rvb1/2p upon ScR2TP Formation.

Figure 6.

The Pih1p-Tah1p-bound Rvb1/2p heterohexamer structure resulted from electron density-guided refinement is compared side by side with the crystal structure of C. thermophilum (Ct) Rvb1/2p complex (PDB: 4WVY) in two orthogonal views. The AAA+ core for both complexes is colored in gray and the insertion domain of Rvb2p is colored magenta for Ct and teal for Sc. DIIINT and DIIEXT denote the insertion domain II internal and external elements (see definition in Figure 1) and are labeled for one Rvb2p subunit. Insets show comparisons of DIIEXT (upper) and DIIINT (lower) conformations between superimposed Ct (magenta) and the Pih1p-Tah1p-bound (teal) Rvb1/2p.