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. 2019 Jul 5;10:854. doi: 10.3389/fphys.2019.00854

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Copyright © 2019 Xu, Zeng, Zhao, Huang, Gao, Dai, Lu, Huang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of SIRT1 activation on apoptosis, renal function and survival time of rats following HS. (A) HS-mediated RTEC apoptosis. The TUNEL positive cells were recognized as apoptotic cells in kidney tissue. (B) Statistical analysis of the TUNEL results. (C) Apoptosis determination of rat RTECs following HS. Apoptosis was reflected by annexin V positive ratio (%). (D,E) Renal function was reflected by serum Cr and BUN following HS. (F) Survival curve analysis of rats following HS. The median survival time was analyzed using Kaplan-Meier plots and compared using the log-rank test. Compared with sham group, ^∗∗ denotes p < 0.01; compared with HS + Vehicle group, ^†† denotes p < 0.01; compared with HS + PD group, ^‡‡ denotes p < 0.01; n = 8. HS, hemorrhagic shock; PD, polydatin; sCr, serum Cr; FITC, fluoresceine isothiocyanate; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling.