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Alectinib inhibits activity of ALK mutants in PC12 cells. (A,B) PC12 cells transiently transfected with either ALK-wt (1.5 μg) or ALK mutant variants as indicated (0.75 μg), were treated with increasing concentrations of either alectinib (A) or crizotinib (B) at 48 h post-transfection. ALK activation was measured by immunoblotting for pALK-Y1604. (C,D) Shows the total ALK levels (as a loading control) for (A,B), respectively.
