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. 2019 Jun 5;20(2):1149–1156. doi: 10.3892/mmr.2019.10349

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Copyright: © Ji et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Downregulation of CDCA7L inhibits glioma cell growth in vivo. (A) The images of mice implanted with intracranial tumors formed by U87 on days 3 and 8. (B) Ki-67 in tumors derived from U87 cells following transfection with CDCA7L siRNA or NC siRNA examined by immunohistochemistry. Scale bar, 100 µm. (C) Downregulation CDCA7L expression reduced the CCND1 expression level in vivo shown by western blot analysis. *P<0.05 indicates statistical significance compared with the NC siRNA group. (D) Kaplan-Meier curves plotted to measure the overall survival in the 2 ×enograft groups. CDCA7L, cell division cycle-associated 7 like; NC, negative control.