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. 2019 Jun 3;20(2):1443–1450. doi: 10.3892/mmr.2019.10319

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — PEDF-induced human umbilical vein endothelial cell autophagy is mediated through inhibition of mechanistic target of rapamycin. (A) Western blot analysis was conducted to examine the alterations in p70S6K and 4E-BP1 phosphorylation in the control, PEDF, PEDF + cont siRNA, PEDF + p53 siRNA and PEDF + sestrin2 siRNA groups. (B) Semi-quantitative analysis of blots in (A). *P<0.05 vs. PEDF-treated group. 4E-BP1, eukaryotic translation initiation factor 4E-binding protein 1; p, phosphorylated; p70S6K, p70S6 kinase; PEDF, pigment epithelium-derived factor; si, small interfering.