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. 2019 Jun 6;20(2):1333–1342. doi: 10.3892/mmr.2019.10363

Figure 5.

Figure 5.

Lidocaine downregulates the expression of EGFR in RB cells. Expression of EGFR (A) mRNA and (B) protein in RB and normal adjacent tissues (a1, a2 and a3, RB tissues; b1, b2 and b3, normal adjacent tissues) n=30/group. Data are presented as the mean ± standard deviation. **P<0.01 vs. normal tissues. Expression of EGFR (C) mRNA and (D) protein in RB cell lines and the retinal pigment epithelial cell line ARPE-19 and RB cell lines. Data are presented as the mean ± standard deviation of three independent experiments performed in triplicate. *P<0.05, **P<0.01 vs. ARPE-19. Expression of EGFR (E) mRNA and (F) protein in Y79 cells following treatment with 500 µM lidocaine for 24 h. Data are presented as the mean ± standard deviation of three independent experiments performed in triplicate. **P<0.01 vs. control. RB, retinoblastoma; EGFR, epidermal growth factor receptor.