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. 2019 Jun 6;20(2):1333–1342. doi: 10.3892/mmr.2019.10363

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Copyright: © Xia et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — Lidocaine inhibits the proliferation and promotes the apoptosis of retinoblastoma cells via upregulation of miR-520a-3p. Y79 cells were transfected with NC or inhibitor for 24 h, and then treated with lidocaine or control for 24 h. (A) Proliferation of Y79 cells as determined by a Cell Counting Kit-8 assay. (B) Apoptosis of Y79 cells as determined by a flow cytometry assay. (C) Early apoptosis Early apoptosis (Q4) and late apoptosis (Q2) were calculated and the apoptosis rate was presented. Data are presented as the mean ± standard deviation of three independent experiments performed in triplicate. **P<0.01 vs. control; ^&&P<0.01 vs. 500 µM lidocaine. NC, negative control; miR-520a-3p, microRNA-520a-3p; inhibitor, miR-520a-3p inhibitor; FITC, fluorescein isothiocyanate; PI, propidium iodide.