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. 2019 Jun 4;20(2):1259–1269. doi: 10.3892/mmr.2019.10336

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Copyright: © Yu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — GO and KEGG enrichment analysis of the overlapping DEGs. (A and B) Top significantly enriched GO terms of down- and upregulated DEGs, including BP, CC and MF. The x-axis represents the number of DEGs involved in GO terms, and the y-axis the significantly enriched GO terms. (C) KEGG pathway enrichment analysis of overlapping DEGs. The x-axis indicates the number of DEGs involved in the significant KEGG pathway, and the y-axis the terms of the significant KEGG pathway. (D) DEGs associated with the significant KEGG pathway. GO, gene ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; DEGs, differentially expressed genes. (a) Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; (b) oxidoreductase activity, acting on CH-OH group of donors; (c) steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; (d) oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; (e) regulation of mitotic cell cycle phase transition; (f) condensed chromosome, centromeric region; (g) condensed nuclear chromosome, centromeric region; (h) chromosome, centromeric region; (i) cyclin-dependent protein serine/threonine kinase regulator activity; (j) transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding.