Table III.
GO analysis of down- and upregulated overlapping DEGs associated with CRC.
| Expression | Terms | ID | Description | q-value | Genes |
|---|---|---|---|---|---|
| Upregulated | BP | GO:0000280 | Nuclear division | 4.33×10−7 | RRS1/CKS2/TRIP13/CCND1/FIGNL1/TPX2/ANLN/UBE2C/CHEK1/NUF2/RAD54B/DLGAP5/CDC6/MAD2L1/TOP2A/TTK/CCNB1/ASPM/BUB1B/AURKA |
| BP | GO:0048285 | Organelle fission | 1.16×10−6 | RRS1/CKS2/TRIP13/CCND1/FIGNL1/TPX2/ANLN/UBE2C/CHEK1/NUF2/RAD54B/DLGAP5/CDC6/MAD2L1/TOP2A/TTK/CCNB1/ASPM/BUB1B/AURKA | |
| BP | GO:0140014 | Mitotic nuclear division | 6.51×10−6 | RRS1/TRIP13/CCND1/TPX2/ANLN/UBE2C/CHEK1/NUF2/DLGAP5/CDC6/MAD2L1/TTK/CCNB1/BUB1B/AURKA | |
| BP | GO:0007088 | Regulation of mitotic nuclear division | 1.18×10−5 | TRIP13/CCND1/ANLN/UBE2C/CHEK1/DLGAP5/CDC6/MAD2L1/TTK/CCNB1/BUB1B/AURKA | |
| BP | GO:0000075 | Cell cycle checkpoint | 1.18×10−5 | TRIP13/CCND1/ARID3A/CHEK1/CDC6/MAD2L1/TOP2A/TTK/CCNB1/SOX4/BUB1B/AURKA/PROX1 | |
| CC | GO:0044452 | Nucleolar part | 4.66×10−5 | TAF1D/DKC1/UTP4/WDR43/NOP58/RRS1/RPP40/NUFIP1/ORC6/POLR1D/E2F5 | |
| CC | GO:0000793 | Condensed chromosome | 4.66×10−5 | RRS1/SKA3/CHEK1/NUF2/CENPA/MAD2L1/TOP2A/CCNB1/SPC25/ERCC6L/BUB1B/AURKA | |
| CC | GO:0000779 | Condensed chromosome, centromeric region | 5.94×10−5 | SKA3/NUF2/CENPA/MAD2L1/CCNB1/SPC25/ERCC6L/BUB1B/AURKA | |
| CC | GO:0000780 | Condensed nuclear Chromosome, centromeric region | 1.13×10−4 | NUF2/CENPA/CCNB1/BUB1B/AURKA | |
| CC | GO:0000776 | Kinetochore | 1.13×10−4 | SKA3/NUF2/CENPA/MAD2L1/TTK/CCNB1/SPC25/ERCC6L/BUB1B | |
| MF | GO:0030515 | snoRNA binding | 2.99×10−3 | DKC1/NOP58/DDX21/NUFIP1 | |
| MF | GO:0009982 | Pseudouridine synthase activity | 3.70×10−3 | PUS1/PUS7/DKC1 | |
| MF | GO:0035173 | Histone kinase activity | 7.05×10−3 | CHEK1/CCNB1/AURKA | |
| MF | GO:0001664 | G protein-coupled receptor binding | 8.09×10−3 | CXCL3/RNF43/HOMER1/NMU/CXCL8/ZNRF3/CXCL1/CTHRC1/CXCL5 | |
| MF | GO:0140098 | Catalytic activity, acting on RNA | 1.15×10−2 | NOB1/PUS1/EXOSC5/NOP2/RPP40/DDX21/RNASEH2A/POLR1D/RAD54B/AZGP1 | |
| Downregulated | BP | GO:0010273 | Detoxification of copper ion | 1.22×10−5 | MT1M/MT1X/MT1E/MT1H/MT1F/MT1G |
| BP | GO:1990169 | Stress response to copper ion | 1.22×10−5 | MT1M/MT1X/MT1E/MT1H/MT1F/MT1G | |
| BP | GO:0061687 | Detoxification of inorganic compound | 1.22×10−5 | MT1M/MT1X/MT1E/MT1H/MT1F/MT1G | |
| BP | GO:0071280 | Cellular response to copper ion | 1.22×10−5 | MT1M/MT1X/MT1E/MT1H/MT1F/MT1G/AOC1 | |
| BP | GO:0097501 | Stress response to metal ion | 1.35×10−5 | MT1M/MT1X/MT1E/MT1H/MT1F/MT1G | |
| CC | GO:0005903 | Brush border | 6.96×10−5 | CDHR5/TRPM6/SCIN/CDHR2/CA4/LIMA1/CYBRD1/MYO1A/SLC26A3/SI | |
| CC | GO:0045177 | Apical part of cell | 3.15×10−4 | ABCG2/CA2/RAB27A/CDHR5/PTPRH/TRPM6/AQP8/CDHR2/CA4/SCNN1B/CLCA4/CEACAM1/FABP1/CEACAM7/MYO1A/SLC26A3/SI | |
| CC | GO:0031526 | Brush border membrane | 3.15×10−4 | CDHR5/TRPM6/CDHR2/CA4/LIMA1/CYBRD1/SLC26A3 | |
| CC | GO:0005902 | Microvillus | 6.78×10−4 | CA2/CDHR5/PTPRH/CDHR2/CEACAM1/CLCA1/AOC3/MYO1A | |
| CC | GO:0098862 | Cluster of actin-based cell projections | 8.31×10−4 | CDHR5/TRPM6/SCIN/CDHR2/CA4/LIMA1/CYBRD1/MYO1A/SLC26A3/SI | |
| MF | GO:0016616 | Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 6.48×10−5 | UGDH/ADH1B/HPGD/LDHD/ADH1C/DHRS11/DHRS9/HSD17B2/AKR1B10/HSD11B2/BMP2 | |
| MF | GO:0016614 | Oxidoreductase activity, acting on CH-OH group of donors | 1.09×10−4 | UGDH/ADH1B/HPGD/LDHD/ADH1C/DHRS11/DHRS9/HSD17B2/AKR1B10/HSD11B2/BMP2 | |
| MF | GO:0004089 | Carbonate dehydratase activity | 1.26×10−4 | CA7/CA2/CA12/CA1/CA4 | |
| MF | GO:0048038 | Quinone binding | 4.90×10−3 | ETFDH/TP53I3/AOC3/AOC1 | |
| MF | GO:0033764 | Steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 1.52×10−2 | DHRS11/DHRS9/HSD17B2/HSD11B2 |
Adjusted P<0.05 was considered to be significant. DEGs, differentially expressed genes; CRC, colorectal cancer; q-value, adjusted P-value; GO, Gene Ontology; BP, biological process; CC, cellular component; MF, molecular function.