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. 2019 Jun 10;20(2):1541–1550. doi: 10.3892/mmr.2019.10371

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Copyright: © Zhu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Curcumin attenuates H/R-induced injury and apoptosis in H9C2 cells. (A) Curcumin reversed the inhibitory effects of H/R on H9C2 cell viability. Curcumin pretreatment attenuated the effects of H/R on the levels of (B) LDH, (C) MDA and (D) SOD. Effects of curcumin on H/R-induced increases in (E) ROS levels and (F) apoptosis. Data are presented as the mean ± standard deviation (n=3). *P<0.05, **P<0.01 vs. Con; ^{^}P<0.05, ^{^^}P<0.01 vs. H/R; ^#P<0.05, ^##P<0.01 vs. Cur. Con, control (normoxic culture conditions); Cur, curcumin; H/R, hypoxia/reoxygenation; LDH, lactate dehydrogenase; MDA, malondialdehyde; OD, optical density; PI, propidium iodide; ROS, reactive oxygen species; SOD, superoxide dismutase.