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. 2019 Jun 10;20(2):1541–1550. doi: 10.3892/mmr.2019.10371

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Copyright: © Zhu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Curcumin pretreatment inhibits the Notch signaling pathway. (A) mRNA and (B) protein expression levels of NICD as determined via RT-qPCR and western blotting, respectively. (C) Expression of downstream genes (Hes-1, Hes-5 and Hey-1) of the Notch pathway as determined via RT-qPCR analysis. GAPDH was used as an internal control. Data are presented as the mean ± standard deviation (n=3). *P<0.05, **P<0.01 vs. Con; ^{^}P<0.05, ^{^^}P<0.01 vs. H/R; ^#P<0.05, ^##P<0.01 vs. Cur. Con, control (normoxic culture conditions); Cur, curcumin; H/R, hypoxia/reoxygenation; Hes, hairy and enhancer of split; Hey-1, hairy/enhancer-of-split related with YRPW motif protein 1; NICD, Notch intracellular domain; RT-qPCR, reverse transcription-quantitative polymerase chain reaction.