Figure 1.

Plasma IL-12 is increased in NOD mice with SS-like symptoms. (A) Plasma levels of IL-12 in 12-week-old NOD and ICR mice were detected by ELISA. (B) Plasma IL-12 and the saliva flow rate in 4- and 8-week-old NOD mice were detected. *P<0.05, n=5. Error bars indicate SEM. (C) H&E staining of SGs for histological analysis (magnification, ×100). Arrows indicate the locus of lymphocytic infiltration in SGs. IL-12, interleukin-12; SS, Sjögren's syndrome; SGs, submandibular glands; H&E, hematoxylin and eosin; W, week.